From the Port of San Diego, Celebrity Cruises, Holland America, Carnival and Royal Caribbean offer cruises through the Panama to both United States coasts plus numerous ports of call in Mexico and Hawaii. These include: Acapulco, Aruba, Baltimore, Baja México, Cabo San Lucas, Cartagena, Catalina Island, Ensenada, Fort Lauderdale, Half Moon Cay, Huatulco, Hilo, Kona, Honolulu, Nawiliwili, Lahaina, Huatulco, Manzanillo Mazatlan, Panama Canal, Puerto Caldera, Puerto Vallarta, Puerto Chiapas, Puerto Quetzal, Punta Renes, San Blas Islands, Santa Marta, Santo Domingo, Topolobampo and Zihuatanejo.

Here's a satellite photo centered on the San Diego Cruise Terminal.